There are various reasons healthcare providers may recommend prescription medications for weight management, and it’s not just about aesthetics. On average, individuals who include medication in their weight loss plans tend to lose up to 12 percent more of their initial body weight than those who don’t use these aids.

Today, there are several FDA-approved weight loss medications available. But do they truly work, and which one is the best? Let’s explore some of the most effective weight loss medications and their efficacy.

Which Medications Are FDA Approved for Weight Loss?

Semaglutide (Compounded Semaglutide, Ozempic, Tirzepatide, Zepbound)
Semaglutide, commonly known under brand names like Ozempic, Wegovy, and Rybelsus, is part of a class of drugs known as GLP-1 receptor agonists. These medications mimic the hormone glucagon-like peptide-1 and help regulate appetite by targeting specific areas of the brain. Ozempic, initially approved by the FDA in 2017 to treat type 2 diabetes, can also be prescribed off-label for weight loss. Wegovy, on the other hand, is specifically approved for weight loss in individuals who are obese or overweight.

Compounded Semaglutide & Ozempic

Semaglutide, under the brand name Ozempic, is a medication that falls under the GLP-1 receptor agonists class. It works by mimicking the hormone GLP-1, which helps regulate appetite and blood sugar levels. Originally approved by the FDA to manage type 2 diabetes, Ozempic has also been found effective in promoting weight loss. When used alongside a healthy diet and exercise, individuals can experience significant weight reduction. It is typically administered as a once-weekly injection.

Tirzepatide
Tirzepatide is a new dual GIP and GLP-1 receptor agonist that works by enhancing insulin secretion, decreasing appetite, and regulating blood sugar. It’s gaining attention for its potential in managing obesity, even though its primary use is in treating type 2 diabetes.

Zepbound
Zepbound is an emerging medication that offers potential benefits for weight management by targeting hunger and satiety mechanisms. Although relatively new, it shows promise in supporting weight loss goals when used in combination with diet and exercise.

Understanding the Role of Weight Loss Medications

Weight management is critical for long-term health, as obesity is linked to various conditions such as heart disease, type 2 diabetes, and certain cancers. In the U.S., nearly 42 percent of adults were classified as obese in 2017, with associated medical costs significantly higher than those of individuals at a healthy weight.

Healthcare providers may prescribe weight loss medications to individuals who have a high body mass index (BMI) and related health conditions like high blood pressure or diabetes. These drugs can be a valuable part of a comprehensive weight management plan, but their effectiveness varies among individuals.

How Effective Are These Medications?

Weight loss medications, when used as prescribed, can be effective. For instance, studies show that non-diabetic individuals who took weekly injections of Wegovy (semaglutide) experienced an average weight loss of nearly 15 percent. Similarly, metformin has shown modest reductions in BMI, particularly in obese individuals.

However, affordability is a key factor to consider. Injectable options like Ozempic and Wegovy can be costly, ranging from $800 to $1,000 per month, whereas generic drugs like metformin are significantly less expensive.

How Quickly Do They Work?

The timeline for weight loss varies. Some people see results within a few months, while others may need to use the medication longer. Healthcare providers often recommend combining these medications with lifestyle changes such as increased physical activity, balanced diets, and healthy sleep habits to maximize results.

Potential Side Effects

All medications have side effects, and weight loss drugs are no exception. Common issues include gastrointestinal discomfort, nausea, vomiting, and diarrhea. For injectable drugs, injection site reactions are also possible. Some medications may increase the risk of pancreatitis or thyroid tumors, though such risks are rare.

The Bottom Line

Weight loss medications, including compounded semaglutide, tirzepatide, Ozempic, Zepbound, and others, offer different mechanisms to support weight loss. While no single medication is best for everyone, a healthcare provider can help you determine the right choice based on your specific needs. Always consult a healthcare professional to explore your options and make informed decisions.